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. 2014 Apr 29;7:10. doi: 10.3389/fneng.2014.00010

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Copyright © 2014 Sohal, Jackson, Jackson, Clowry, Vassilevski, O’Neill and Baker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The astrocytic response over a 6 (rabbit J, L), 12(rabbit P), and 24 (rabbit-N) month chronic indwelling period. (A) Representative images for the astrocytic response for both electrode types at the 6 month time point. Note the interaction between the two microwire recording sites. White concentric rings show an illustrative example of measurements taken for the radial distribution intensity as a function of distance from the electrode implantation site. (B) Representative images for the astrocytic response for both electrode types at the 12 month time point. (C) Representative images for the astrocytic response for both electrode types at the 24 month time point. (D) Overall normalized integrated intensity response (±SEM) for both electrode types for the 6 month time point (n = 30 electrode tracts). Significant differences (gray shading) were found at 50–250 μm away from the electrode implantation site (P < 0.05). (E) Overall normalized integrated intensity response (±SEM) for both electrode types for the 12 month time point (n = 15 electrode tracts). No significant differences were found. (F) Overall normalized integrated intensity response (±SEM) for both electrode types for the 24 month time point (n = 15 electrode tracts). Significant differences were found at 50 and 150–450 μm away from the electrode implantation site (P < 0.05).