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. 2014 Apr 29;8:140. doi: 10.3389/fnbeh.2014.00140

Figure 2.

Figure 2

Impairment of place preference learning is associated with reduced hippocampal long-term potentiation (LTP). (A) LTP in the CA1 hippocampal pathway was similar in valproate-treated (n = 7) and control (n = 8) C57BL/6 mice. (B) LTP was significantly reduced in valproate-treated BALB/c mice (n = 7) as compared to the control animals (n = 7; repeated measures ANOVA: F(1, 12) = 8.19 p < 0.05). (C) Valproate-treated (n = 36) and control (n = 41) C57BL/6 mice acquired place preference at the same level. (D) Valproate-treated BALB/c mice (n = 42) showed impaired place preference learning comparing to the control animals (n = 29; Mann-Whitney U-Test comparisons of two independent groups). Dots represent the actual data, while dashed lines serve to guide the eye. Error bars represent s.e.m. *p < 0.05, ***p < 0.001.