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. 2014 Apr 29;8:140. doi: 10.3389/fnbeh.2014.00140

Figure 4.

Figure 4

Fear conditioned valproate-treated C57BL/6 mice but not BALB/c mice exhibit lower level of freezing during fear extinction and decreased contextual fear renewal. (A) During extinction session valproate-treated C57BL/6 mice (n = 20) decreased freezing response to the conditioned stimulus to a larger degree than the control animals, as well as showed decreased fear renewal to the conditioning context. (B) Such differences were not observed in valproate-treated BALB/c mice. Dots represent the actual data, while dashed lines serve to guide the eye. Error bars represent s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001 (Mann-Whitney U-Test for comparisons of two independent groups: C57BL/6 or BALB/c control vs. valproate-treated mice).