Table 2.
Gray matter volume (GMV) analysis results: (A) brain regions showing significant differences in GMV between healthy controls (HC) and obstructive sleep apnea syndrome (OSAS) patients; (B) brain regions showing significant correlation with the apnea–hypopnea index (AHI) or with nocturnal hypoxemia duration in OSAS patients (MNI coord.; 20 vox., uncorrected p < 0.001).
| Region | Brodmann area | X | Y | Z | Z-score | Cluster size | |
|---|---|---|---|---|---|---|---|
| (A) COMPARISON BETWEEN HC AND OSAS PATIENTS | |||||||
| HC > OSAS | L middle frontal gyrus | 46 | −43 | 44 | 9 | 3.31 | 52 |
| HC < OSAS | R precuneus | 7 | 18 | −52 | 41 | 3.74 | 161 |
| R occipital fusiform gyrus | 18 | 26 | −87 | −19 | 3.56 | 69 | |
| R occipital lingual gyrus | 18 | 2 | −86 | −7 | 3.41 | 123 | |
| (B) CORRELATIONS IN OSAS PATIENTS | |||||||
| AHI positive | L postcentral gyrus/inferior parietal lobe | 40 | −45 | −27 | 26 | 3.74 | 123 |
| AHI negative | L medial frontal gyrus | 11 | −1 | 48 | −17 | 4.07 | 229 |
| R uncus | 36 | 21 | 1 | −35 | 3.80 | 187 | |
| R precuneus | 7 | 18 | −71 | 44 | 3.78 | 97 | |
| Desaturation positive | L precuneus | 7 | −17 | −60 | 44 | 4.70 | 96 |
| Desaturation negative | R superior temporal gyrus | 38 | 46 | 15 | −33 | 4.17 | 602 |
| L middle temporal gyrus | 21 | −52 | 6 | −22 | 3.94 | 383 | |
| R uncus | 36 | 24 | 1 | −30 | 3.79 | 198 | |