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P2Y receptors, their preferred ligands, and G protein coupling
| P2Y Receptor | Preferred Ligand (EC50, µM) | Coupling |
|---|---|---|
| P2Y1 | ADP (1) > ATP (4) | Gq |
| P2Y2 | UTP (0.14) ≈ ATP (0.23) | Gq |
| P2Y4 | UTP (2.5) [rodent: UTP (2.6) ≈ ATP (1.8)] | Gq |
| P2Y6 | UDP (0.300) > UTP (6) > ADP (30) | Gq |
| P2Y11 | ATP (17.4) | Gq/Gs |
| P2Y12 | ADP (60.7) | Gi |
| P2Y13 | ADP (60) > ATP (261) | Gi |
| P2Y14 | UDP-glucose (80) > UDP-galactose (124) | Gi |
