. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Best Pract Res Clin Rheumatol. 2014 Feb;28(1):61–71. doi: 10.1016/j.berh.2014.01.007

Table 1.

X-ray and MRI measures being obtained in the FNIH OA Biomarkers Consortium.

Imaging Biomarker	Proposed Analytic Group	Parameter{s) Measured
Radiography
Minimum Joint space width and joint space area and BTI/FSA	Duke Image Analysis Lab (DIAL)	Medial and lateral and minimum JSW and joint space area (JSA) and medial and lateral bone trabecular integrity by fractal signature analysis, (BTI/FSA)
MRI
Quantitative cartilage morphometry	Chondrometrics	Cartilage Volume, thickness, denuded surface area
Quantitative bone morphometry	4Q imaging	Bone area, osteophyte volume and the bone/cartilage interface signal contrast
Quantitative bone morphometry	Imorphics	3 dimensional bone shape
Semi-quantitative joint scoring	Boston Image Core Lab (BICL)	Assessment of the joint organ morphology using the using the MRI Osteoarthritis Knee Score (MOAKS) system