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. 2014 May 5;211(5):943–959. doi: 10.1084/jem.20130790

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© 2014 Xiao et al.

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Figure 8. — Impact of RGMb–PD-L2 blockade on tolerance induction is not caused by depletion of APC. (a–c) Mice immunized with OVA in ALUM on day 0 received OVA i.n. on days 7–9 and were treated with PD-L2 mAb 2C9 or isotype control (500 µg i.p.) on day 8. Lung cells were dispersed on day 10 and the expression of PD-L2 analyzed on AMs (F4/80⁺CD11c⁺), DCs (F4/80⁻CD11c⁺), and IMs (F4/80⁺CD11c^lo). (a) Gating strategy used in b–d. (b) Solid line indicates staining with PD-L2 mAb TY25; shaded histogram indicates isotype control. One mouse/group representative of three is shown. (c) The number of PD-L2⁺ macrophages and DCs was quantified. Data are representative of two experiments.