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. 2014 May;196(10):1853–1865. doi: 10.1128/JB.01483-13

TABLE 3.

Genes influenced by HupB

Gene and regulation in M. tuberculosis ΔhupB mutant strain Locus no. Fold change in transcript levelsa
 Gene productd
M. tuberculosis LI versus HIb P valuec LI M. tuberculosis ΔhupB versus LI M. tuberculosis P valuec
Downregulated
    papA3 Rv1182 −0.3505 0.6086 −4.6442 0.0008 Polyketide synthase PapA3
    pks4 Rv1181 −0.2466 0.5339 −2.8671 0.0012 Polyketide β-ketoacyl synthase Pks4
    mmpL10 Rv1183 0.2518 0.5756 −2.7384 0.0001 CTMP
Upregulated
    rv2087 Rv2087 0.0753 0.9265 5.6351 0.0000 CHP
    adh Rv1530 0.0130 0.9160 4.3850 0.0005 Alcohol dehydrogenase Adh
    rv0368c Rv0368c −0.1614 0.3291 4.2487 0.0001 CHP
    phyA Rv3397c −0.0639 0.6855 3.8625 0.0005 Phytoene synthase PhyA
    rv1128c Rv1128c 0.0709 0.9691 3.8387 0.0000 CHP
    wbbL2 Rv1525 0.1132 0.6176 3.3595 0.0001 Rhamnosyltransferase
    rv0370c Rv0370c 0.4890 0.7476 3.3381 0.0003 Oxidoreductase
    rv2813 Rv2813 −0.3329 0.6245 3.3066 0.0001 CHP
    rv3468c Rv3468c 0.4669 0.0427 3.1401 0.0000 Glucose 4,6-dehydratase
    rv2650c Rv2650c −0.3239 0.2691 3.0965 0.0002 PhirV2 prophage protein
    rv0369c Rv0369c 0.0473 0.9359 3.0357 0.0001 Membrane oxidoreductase
    rv1672c Rv1672c −0.4033 0.3545 2.8369 0.0030 CMP
    rv3467 Rv3467 0.3043 0.4444 2.7850 0.0001 CHP
    ppe63 Rv3539 −0.2336 0.2688 2.7844 0.0001 PPE family protein
    rv1531 Rv1531 −0.1800 0.5454 2.7837 0.0017 CHP
    rv1371 Rv1371 −0.4599 0.0010 2.7471 0.0039 CMP
    eccD4 Rv3448 0.1652 0.5485 2.7374 0.0720 ESX conserved component EccD4; ESX-4 type VII secretion system protein
    ppsC Rv2933 0.2150 0.1214 2.7292 0.0084 Polyketide synthase PpsC
    ptrBa Rv0781 −0.1376 0.1433 2.7287 0.0000 Protease oligopeptidase B
    ugpC Rv2832c 0.1324 0.6836 2.6397 0.0000 Sn-glycerol-3-phosphate transport ATP-binding protein
    vapB18 Rv2545 0.2859 0.5003 2.6258 0.0001 Possible antitoxin VapB18
    rv1730c Rv1730c 0.4089 0.6665 2.6037 0.0086 Penicillin-binding protein
    rv3529c Rv3529c 0.0210 0.8116 2.6024 0.0000 CHP
    nat Rv3566c −0.0945 0.6782 2.5998 0.0009 Arylamine N-acetyltransferase
    rv3530c Rv3530c −0.0996 0.6622 2.5953 0.0006 Oxidoreductase
    iunH Rv3393 0.4561 0.0181 2.5347 0.0000 Nucleoside hydrolase
    rv3376 Rv3376 0.2323 0.2552 2.5015 0.0000 CHP
a

Fold changes of ≥2 in transcript levels were considered.

b

HI and LI represent high (8 μg Fe ml−1)- and low (0.02 μg Fe ml−1)-iron conditions of growth.

c

The P values were calculated based on multiple probes used for each gene using the t test method.

d

Gene products are indicated as described by Mycobacterial Browser (Mycobrowser; Tuberculist version 2.6; http://tuberculist.epfl.ch/), except that the terms “probable” and “possible” are removed. CHP, conserved hypothetical protein; CMP, conserved membrane protein; CTMP, conserved transmembrane protein.