TABLE 2.
Comparison of the MMAR_1663-MMAR_1668 genomic regions in M. marinum and M. tuberculosis
| M. marinum gene | M. tuberculosis gene | % Amino acid identity | Proposed function (reference)a |
|---|---|---|---|
| MMAR_1663 | Rv3038c | 87 | Conserved hypothetical ortholog, MeT; essential for in vitro growth in M. tuberculosis (54) |
| MMAR_1664 | Rv3037c | 77 | Conserved hypothetical ortholog, SAM-MeT; essential for growth in macrophages in M. tuberculosis (63) |
| MMAR_1665 | Rv3036c (TB22.2) | 79 | Conserved hypothetical secreted/outer membrane protein; similar to MPT-64 |
| MMAR_1666 | Not conserved | NAb | Hypothetical membrane protein |
| MMAR_1667 | Rv3035 | 82 | Conserved protein; ortholog, pyrrolo-quinoline quinone/8-blade beta propeller |
| Essential for in vitro growth in M. tuberculosis (54) | |||
| MMAR_1668 | Rv3034c | 93 | Possible maltose O-transferase family; essential for in vitro growth in M. tuberculosis (54) |
a
Proposed functions collected from MycoBrowser, the TB Database, and NCBI BLAST. MeT, methyltransferase.
b
NA, not applicable.