Skip to main content
. Author manuscript; available in PMC: 2014 May 6.
Published in final edited form as: Nat Immunol. 2010 Aug 8;11(9):862–871. doi: 10.1038/ni.1917

Figure 7.

Figure 7

Engagement of CD46 by locally produced C3b drives IL-10 expression in CD4+ T cells stimulated with anti-CD3 and anti-CD28. (a) Flow cytometry of C3b surface deposition on purified CD4+ T cells either not activated or activated for 12 h with immobilized mAbs (key). Data are representative of four experiments. (b) Production of IL-10 by purified T cells either not activated or activated for 36 h with mAb to CD3 alone or mAb to CD3 plus mAb to CD28 (horizontal axis) plus media alone or media plus soluble CD46 (sCD46; key). NS, not significant; *P < 0.01 (Student’s t-test). Data are representative of three experiments.