Fig. 7. Species distribution diagram for Ins(1,3,4,5,6)P ₅ in the presence of Na⁺ (a) or Mg²⁺ (b). Predictions are for [Ins(1,3,4,5,6)P ₅] = 4.8 mM, [Na⁺] = 0.5 M (a) or [Ins(1,3,4,5,6)P ₅] = 2.5 mM, [Mg²⁺] = 1.0 mM (b), in 0.15 M NMe₄Cl and 37.0 °C. The pH range in which the ligand conformational change takes place is highlighted in each case.