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. Author manuscript; available in PMC: 2014 May 6.
Published in final edited form as: Genes Brain Behav. 2012 Aug 31;12(1):87–97. doi: 10.1111/j.1601-183X.2012.00834.x

Figure 5. Nervous system-specific loss of Taok2 in mice alters ethanol-induced sedation and consumption.

Figure 5

(a) Taok2tm1fl/fl;Nes-cre mice (n = 8) show increased recovery time relative to control animals (n = 6) to 4g/kg ethanol in the loss of right reflex (LORR) assay. (b) Normal metabolism of a 4g/kg dose of ethanol is observed in Taok2tm1fl/fl;Nes-cre mice (n = 5) compared to controls (n = 6). (c) Taok2tm1fl/fl;Nes-cre mice (n = 12) consume more ethanol than controls (n = 9) in a limited-access, drinking in the dark (DID) assay. (d) BEC levels are comparable between Taok2tm1fl/fl;Nes-cre and control mice on the final day of ethanol access (e) H20 consumption is normal in Taok2tm1fl/fl;Nes-cre mice. BEC = blood ethanol content. Error bars are mean ± SEM. Asterisks indicate level of significance (* P < 0.05).