Table IIIA.

Association Analysis by PDTPHASE Between PIP4K2A Markers and Schizophrenia According to Offspring Sex in the ISHDSF Sample

	P-values (male affecteds)				P-values (female affecteds)
Single markers	d2	d5	d8	d9	d2	d5	d8	d9
rs1417374	0.641	0.640	0.721	0.883	0.140	0.066	0.114	0.098
rs1409375	0.677	0.738	0.721	0.795	0.076	0.060	0.042	0.061
rs10828317	0.965	0.677	0.816	0.505	0.978	0.634	0.650	0.710
rs746203	0.808	0.670	0.605	0.398	0.634	0.619	0.340	0.884
PIK53_54	0.689	0.864	0.743	0.874	0.788	0.519	0.352	0.311
rs2364115	0.957	0.409	0.441	0.438	0.927	0.509	0.409	0.617
Haplotype
rs1417374-rs1409375	0.316	0.440	0.509	0.713	0.164	0.120	0.137	0.148

Detailed output for rs1409375 to show under-transmission of common allele to affected females
d8
All offspring
Allele	Z	P	Trio-T	Trio-NT	AffSib	UnafSib	Freq
1	−0.9715	0.3313	857	859.7	943	956	0.6798
2	0.9715	0.3313	411	408.3	393	380	0.3202
Global test: chi-sq 0.9438, P 0.3313

d8
Male affected offspring
Allele	Z	P	Trio-T	Trio-NT	AffSib	UnafSib	Freq
1	0.3569	0.7212	566	548.8	301	293	0.6867
2	−0.3569	0.7212	246	263.2	109	117	0.3133
Global test: chi-sq 0.1274, P 0.7212

d8
Female affected offspring
Allele	Z	P	Trio-T	Trio-NT	AffSib	UnafSib	Freq
1	−2.038	0.04154	291	314	155	173	0.6767
2	2.038	0.04154	165	142	99	81	0.3233
Global test: chi-sq 4.154, P 0.04154

Significant (uncorrected) P-values are shown in bold, those showing a trend in gray.