Table 4. Pharmcokinetic parameters of CMAB001 after multiple-dose infusions of 1.0 mg/kg in patients with chronic plaque psoriasis (n=10). MRT, mean retention time.
| Parameters | AUC0–z (d·μg·mL−1) | AUC0–∞ (d·μg·mL−1) | MRT (d) | Clss (mL·d−1·kg−1) | Vss (mL·kg−1) | t1/2 (d) | Cmax (μg·mL−1) | Tmax (d) |
|---|---|---|---|---|---|---|---|---|
| 1 | 133.96 | 136.53 | 12.01 | 16.4 | 177.4 | 7.48 | 10.984 | 7.48 |
| 2 | 94.59 | 96.66 | 12.49 | 23.9 | 265.6 | 7.70 | 6.911 | 7.70 |
| 3 | 106.13 | 108.95 | 13.42 | 22.4 | 267.6 | 8.29 | 7.361 | 8.29 |
| 4 | 68.11 | 70.28 | 12.52 | 32.8 | 400.7 | 8.46 | 5.106 | 8.46 |
| 5 | 65.68 | 67.21 | 12.14 | 33.6 | 383.1 | 7.92 | 4.973 | 7.92 |
| 6 | 87.41 | 90.00 | 13.99 | 28.0 | 351.3 | 8.69 | 5.961 | 8.69 |
| 7 | 73.54 | 74.70 | 12.45 | 30.7 | 317.2 | 7.15 | 5.362 | 7.15 |
| 8 | 59.60 | 61.40 | 12.02 | 36.6 | 434.3 | 8.23 | 4.667 | 8.23 |
| 9 | 83.66 | 86.06 | 13.40 | 28.3 | 345.3 | 8.45 | 5.814 | 8.45 |
| 10 | 101.40 | 103.35 | 13.97 | 24.4 | 279.9 | 7.95 | 6.722 | 7.95 |
| mean | 87.41 | 89.51 | 12.84 | 27.7 | 322.2 | 8.03 | 6.386 | 8.03 |
| SD | 22.58 | 22.90 | 0.78 | 6.0 | 76.6 | 0.48 | 1.845 | 0.48 |