Figure 1.

Morphological and lung Rw/d changes in lungs at 6 h after the induction of ALI with or without SO₂ pretreatment. (A) Morphological changes in the lung by H&E staining. a) Control group with normal lung morphology; b) SO₂ administration alone with lung morphology similar to the control group; c) Six hours after induction of LPS-induced ALI we observed patching hemorrhage and inflammatory cell accumulation in the alveolar space (★), interalveolar septum thickening (•), edema of lung interstitium and alveoli, interstitial and intra-alveolar hemorrhage (▴), and even some alveolus atelectasis and fusion; d) SO₂ pretreatment ameliorated the lung injury induced by LPS. Scale bar, 50 μm. (B) Effect of SO₂ on the total lung injury score. (C) Effect of SO₂ on lung Rw/d 6 h after intratracheal instillation of LPS. Data are presented as the mean±SD (n=7 in each group). ^cP<0.01 compared with the control group; ^eP<0.05 compared with the LPS group.