Figure 2.

Effect of CpG ODNs on the growth of B16 melanoma in mice. C57BL/6 mice were inoculated sc with 2×10⁶ B16 melanoma cells on d 0. Mice were treated with ODN1826 (positive control) and ODN10 at the indicated times and doses. (A) Dose-dependent effect of ODN10 (on d 9, 12, 14; at doses of 1, 5, and 25 mg/kg). (B) Tumor growth curve on d 20 post tumor inoculation at doses of 5 mg/kg at the indicated times (on d 9, 12, 16, and 19). ^bP<0.05, ^cP<0.01 vs PBS-treated mice; (C) Tumor growth inhibitory rate (TGI%) on d 20. ^cP<0.01 vs ODN1826-treated mice. There were 10 mice in each group. The data shown represent two replicate experiments.