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Tumor tissues were fixed in 4% buffered paraformaldehyde, embedded in paraffin and analysed histologically by H&E staining (×132). PBS-treated tumors showed a solid growth pattern without necrosis (A). Tumors treated with ODN1826 (B) or ODN10 (C) exhibited extensive cellular polymorphism, including cavitate nuclei (arrow&1circ;), swollen nuclei (arrow&2circ;), and apoptosis (arrow&3circ;).
