Table 1. Pharmacokinetic parameters of diclofenac in normal and FCAinduced arthritis rats following iv 10 mg/kg diclofenac (mean±SEM).
| Parameter | Normal | Arthritis |
|---|---|---|
| α (h−1) | 3.6±0.2 | 4.4±1.7 |
| β (h−1) | 0.2±0.1 | 0.3±0.1 |
| A (μg/mL) | 86.9±3.1 | 75.5±15.9 |
| B (μg/mL) | 2.9±0.6 | 6.4±3.9 |
| CL1 [L/(kg·h)] | 0.3±0.02 | 0.2±0.03 |
| AUC (μg·h)/mL | 40.0±2.9 | 52.0±11.9 |
| C5 min (μg/mL) | 66.2±4.1 | 53.9±4.9 |
| Beta t1/2 (h) | 3.3±0.8 | 3.2±0.9 |
| V1 (L) | 0.11±0.005 | 0.14±0.02 |
CL1, apparent plasma clearance of the central compartment; V1, apparent volumes of distribution of the central compartment.