Table 2. Pharmacokinetics parameters of prasugrel in Chinese healthy subjects.
| Parameters |
Prasugrel dose mean (CV%) |
||||
|---|---|---|---|---|---|
| 60 mg LD | 30 mg LD | 10 mg MD | 7.5 mg MD | 5 mg MD | |
| D 1 | D 1 | D 11 | D 11 | D 11 | |
| n | 12 | 24 | 12 | 11 | 12 |
| Cmax (ng/mL) | 631.0 (36) | 307.0 (32) | 106.0 (32) | 71.1 (31) | 42.5 (35) |
| Tmax (h)a | 0.50 (0.25–1.00) | 0.50 (0.25–1.00) | 0.50 (0.25–0.50) | 0.50 (0.25–0.50) | 0.50 (0.25–1.00) |
| AUC0–tlast (ng·h·mL−1) | 649.0 (30) | 309.0 (24) | 95.9 (32) | 58.3 (28) | 40.1 (32) |
| AUC0–4 h (ng·h·mL−1) | 604.0 (31) | 291.0 (24) | 91.8 (31) | 56.1 (27) | 39.1 (29) |
| Previous study6 | |||||
| n | 25 | NA | 17 | NA | 25 |
| Cmax (ng/mL) | 614.0 (55) | NA | 101.0(41) | NA | 47.9 (56) |
| AUC0–tlast (ng·h·mL−1) | 653.0 (48) | NA | 94.7 (43) | NA | 42.4 (48) |
AUC0–tlast, area under the serum concentration-time curve from time of dosing through the sampling time of the last quantifiable concentration; AUC0–4 h, area under the serum concentration-time curve through 4 h post dose; Cmax, maximum observed concentration; CV, coefficient of variation; LD, loading dose; MD, maintenance dose; n, number of subjects; NA, not assessed; Tmax, time of maximum observed serum concentration. aMedian (range).