Figure 1.

Schematic structure of the whole-body PBPK model used to predict in vivo behaviors of bisoprolol in different human populations. The blood flow rates associatied with the 14 compartments- lung (Lu), liver (Li), spleen (Sp), gut (AC), adipose (Ad), muscle (Mu), heart (He), brain (Br), kidney (Ki), skin (Sk), reproductive organ (RO), red marrow (RM), yellow marrow (YM), rest of body (ROB), — are represented by Q, subscripted with the corresponding compartment. Q_ha is the blood flow rate to the liver via hepatic artery (ha).