Table 6. Observed and simulated pharmacokinetic parameters of bisoprolol after oral administration of 10 mg in healthy adults using different values of stomach transit time.
| STT (h) | AUC (μg·h/L) |
Cmax (ng/mL) |
Tmax (h) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Observed | Predicted | Fold-error | Observed | Predicted | Fold-error | Observed | Predicted | Fold-error | |
| 0.25a | 427 | 380 | 1.12 | 33.2 | 37.3 | 1.12 | 3.0 | 1.5 | 2.00 |
| 0.6b | 427 | 379 | 1.13 | 33.2 | 34.4 | 1.04 | 3.0 | 2.1 | 1.43 |
Note: STT, stomach transit time; a The initial value of STT; b The final value of STT was fitted to the observed in vivo data after 10 mg oral dose.