Table 5.

Knee Pain Scale Pain Frequency and Pain Severity Scores in Individual Treated Knees Over Time

	RCT waitlist and placebo injection control			Current study
	Baseline RCT control (N=27)	Week 24 RCT control (N=24)	Week 52 RCT control (N=26)	Baseline Prior-Control (N=27) Prior-Decline (N=8) Prior-Ineligible (N=22)	Week 5 Prior-Control (N=27) Prior-Decline (N=6) Prior-Ineligible (N=22)	Week 9 Prior-Control (N=27) Prior-Decline (N=6) Prior-Ineligible (N=22)	Week 12 Prior-Control (N=27) Prior-Decline (N=6) Prior-Ineligible (N=22)	Week 24 Prior-Control (N=26) Prior-Decline (N=6) Prior-Ineligible (N=22)	Week 52 Prior-Control (N=25) Prior-Decline (N=6) Prior-Ineligible (N=22)
KPS Pain Frequency mean (SE) [N]
Prior-Control	3.2 (0.2)	2.8 (0.2)	3.0 (0.2)	3.3 (0.2)	3.2 (0.2)	2.8 (0.2)	3.0 (0.2)	2.9 (0.2)	2.8 (0.2)
Prior-Decline				3.7 (0.3)	2.5 (0.4)	2.8 (0.4)	2.6 (0.4)	3.1 (0.4)	3.5 (0.4)
Prior-Ineligible				3.2 (0.2)	2.8 (0.2)	2.4 (0.2)	2.6 (0.2)	2.6 (0.2)	2.5 (0.2)
KPS Pain Severity mean (SE)
Prior-Control	2.6 (0.2)	2.4 (0.2)	2.9 (0.2)	2.9 (0.2)	2.6 (0.2)	2.2 (0.2)	2.3 (0.2)	2.1 (0.2)	2.0 (0.2)
Prior-Declined				3.0 (0.3)	2.2 (0.3)	2.1 (0.3)	2.0 (0.3)	2.6 (0.3)	2.5 (0.3)
Prior-Ineligible				2.8 (0.2)	2.4 (0.2)	2.0 (0.2)	2.0 (0.2)	2.1 (0.2)	1.9 (0.2)

Repeated-measures analysis of variance compared between-group KPS scores.

Nine Prior-Control participants had both knees treated (18 knees) and 9 participants had one knee treated, resulting in a total of 27 individual knees for the KPS analysis.

Three Prior-Decline participants had both knees treated (6 knees) and 2 participants had one knee treated, contributing 8 individual knees to the KPS analysis.

Seven Prior-Ineligible participants had both knees treated (14 knees) and 8 participants had one knee treated, contributing 22 individual knees to the KPS analysis.

SE, standard error.