Table 4.
Associations between kidney function and mortality in those patients with PH
| Variables | Unadjusted Hazard Ratio (95% Confidence Interval; n=1088) | Adjusteda Hazard Ratio (95% Confidence Interval; n=1088) |
|---|---|---|
| Categorical analysis | ||
| Kidney disease (ml/min per 1.73 m2) | ||
| eGFR≥60 (reference) | ||
| eGFR=30–59 | 1.66 (1.39 to 1.98) | 1.37 (1.14 to 1.66) |
| eGFR=15–29 | 3.94 (2.82 to 5.49) | 2.69 (1.88 to 3.86) |
| Continuous analysis | ||
| For each 5 ml/min per 1.73 m2 lower eGFR | 1.07 (1.05 to 1.09) | 1.05 (1.03 to 1.07) |
| Other variablesb | ||
| Age (for each higher year) | 1.02 (1.01 to 1.03) | |
| Women | 0.78 (0.64 to 0.95) | |
| Hemoglobin (for each 1 g/dl higher) | 0.94 (0.90 to 0.97) | |
| Albumin (for each 1 mg/dl higher) | 0.64 (0.55 to 0.74) | |
| Mean right atrial pressure (for each 1 mmHg higher) | 1.02 (1.00 to 1.03) | |
| Mean pulmonary arterial pressure (for each 1 mmHg higher) | 1.01 (1.01 to 1.02) | |
| Pulmonary capillary wedge pressure (for each 1 mmHg higher) | 0.99 (0.98 to 1.00) | |
| PH class | ||
| I (PAH) | Reference | |
| II (PVH) | 0.71 (0.54 to 0.93) | |
| III (PH lung disease) | 1.44 (1.06 to 1.94) | |
| IV (PH CTED) | 0.68 (0.42 to 1.09) | |
| V (miscellaneous) | 1.18 (0.85 to 1.63) |
a
Adjusted for age, sex, race, diabetes, hypertension, BMI, albumin, hemoglobin, cardiac output, mean pulmonary arterial pressure, mean right atrial pressure, pulmonary capillary wedge pressure, EF, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, diuretics, and PH classification as well as dummy indicators for missing data.
b
Results based on the variables included in the categorical model.