Table 4.
Multivariable analysis of risk factors for lymphedema after mastectomy (≥10% WAC)
| Hazard Ratio | 95% Confidence Interval | P Value | ||
|---|---|---|---|---|
|
| ||||
| BMI at diagnosis, kg/m2 | 1.071 | 1.037 | 1.106 | <0.0001 |
|
| ||||
| Age at diagnosis, years | 1.032 | 1.012 | 1.053 | 0.0021 |
|
| ||||
| Immediate breast reconstruction | 0.623 | 0.395 | 0.983 | 0.0418 |
|
| ||||
| # LN’s Removed | 1.046 | 1.020 | 1.073 | 0.0006 |
|
| ||||
| ALND vs. SLNB | - | - | - | 0.0001 |
|
| ||||
| Radiation Therapy | - | - | - | 0.0017 |
|
| ||||
| Interaction, ALND*RT | - | - | - | 0.0050 |
| SLNB-RT vs. SLNB-no RT | 6.4902 | 2.0183 | 20.8698 | 0.0017 |
| ALND-no RT vs. SLNB-RT | 0.9803 | 0.3367 | 2.8541 | 0.9709 |
| ALND-RT vs. SLNB-RT | 1.0468 | 0.3623 | 3.0245 | 0.9327 |
| ALND-RT vs. ALND-no RT | 1.0678 | 0.6662 | 1.7114 | 0.7853 |
Abbreviations: BMI = Body Mass Index, ALND = Axillary lymph node dissection, LN = lymph node
Note: HR’s for ALND vs. SLNB and Radiation Therapy are blank due to the inclusion of the interaction term (ALND*RT)