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. 2014 Jan 20;5(4):1038–1051. doi: 10.18632/oncotarget.1637

Figure 5. IL-6 is controlled by the kynurenine receptor AHR.

Figure 5

A, Expression of CYP1A1 in NCI-H596 cells after 24 h of IDO1 knockdown (siIDO1) in comparison to control (siC). B, IL-6 mRNA expression of tryptophan-starved NCI-H596 cells in response to 1 nM TCDD or 30 μM kynurenine (KYN), measured after 24 h. C, IL-6 secretion of tryptophan-starved NCI-H596 cells after 72 h treatment with 30 μM kynurenine (KYN), measured by ELISA. D, IL-6 mRNA expression in SKOV-3 cells with a stable AHR knockdown (shAHR) in comparison to control (shC). E, Correlation of AHR and IL-6 protein in NSCLC tissue (n=10). F, Correlation of IL-6 and AHR expression in B-cell lymphoma [27]. G, IL-6 transcript in NCI-H596 cells, measured 72 h after IDO1 knockdown (siIDO1) in comparison to control (siC). H, Expression of IL-6 in SKOV-3 cells after 120 h of tryptophan depletion in comparison to control. Asterisk indicates p<0.05, error bars indicate s.e.m.