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. 2014 Jan 21;5(4):959–969. doi: 10.18632/oncotarget.1360

Figure 5. The engineered repressors block mutant ARs activated by androgen and antiandrogens.

Figure 5

COS-1 cells were transiently transfected with vectors for the (a) H874Y or (b) T877A mutant ARs, TAT-GRE-E1B-LUC, PDM-LACZ-β-GAL and the repressors or interaction motif. EtOH – ethanol, MIB - mibolerone, CPA - cyproterone acetate, OHF - hydroxyflutamide. Mean ±1SE. T-Test * p<0.05, ** p<0.005, ***p<0.0005.