Table 4. Periodontal immunohystochemical and serum nitrosative stress parameters of the patients.
| Parameter | SRP+placebo |
SRP+SDD |
||||
|---|---|---|---|---|---|---|
| Baseline mean±SD | 3 month mean±SD | P | Baseline mean±SD | 3 month mean±SD | P | |
| iNOS+ Leukocytes | 265.8±14 | 181.9±11.7 | 1.05E-93 | 265.9±1.29 | 92.8±21.4 | 1.1E-123 |
| iNOS+ PMN | 172.3±19.9 | 133.3±34.5 | 1.58E-16 | 173.02±2.09 | 79.3±29.1 | 9.67E-88 |
| iNOS+ Monocytes | 121.3±31.7 | 22.8±3.0 | 5.7E-68 | 122.6±2.77 | 13.5±7.7 | 9.67E-88 |
| % iNOS+ Leukocytes | 94.8±3.4 | 90.75±5.75 | 0.06 | 93.9±0.36 | 81.9±10.4 | 0.05 |
| 3NT+ Leukocytes | 219.5±16.50 | 137.3±20.05 | 1.07E-27 | 217.7±4.54 | 101.9±12.73 | 3.44E-70 |
| 3NT+ PMN | 129.9±13.90 | 93.3±12.75 | 0.0087 | 128.3±3.85 | 71.3±9.62 | 1.85E-32 |
| 3NT+ Monocytes | 89.7±8.07 | 44.1±3.14 | 5.35E-15 | 91.5±3.31 | 30.6±6.89 | 7.3E-72 |
| % 3NT+ Leukocytes | 92.3±1.12 | 87.7±1.21 | 0.06 | 90.7±0.94 | 82.9±8.98 | 0.05 |
| NOx (μmol/L) | 69.89±2.43 | 58.69±3.01 | 0.0416 | 68.74±7.31 | 47.16±3.10 | 4.85E-24 |
| 3NT (μmol/L) | 465.57±18.63 | 199.00±10.29 | 3.69E-43 | 464.93±5.76 | 81.43±15.86 | 4.86E-57 |
iNOS+=induced nitric oxide synthase positive cells; 3NT+=3-nitrotyrosine positive cells; PMN=polymorphonuclear leukocytes; NOx=serum nitrites and nitrates; 3NT=serum 3-nitrotyrosine; SRP=scaling and root planning; SDD=subantimicrobial-dose doxycycline; P=statistical significance baseline compared with 3 months.