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The anti-hematologic malignancies mechanisms of GA. GA induces hematologic malignancies cells apoptosis via regulating the expression and intracellular positioning of nucleoporin and nucleophosmin (NPM); down-regulating steroid receptor coactivator-3 (SRC-3) as well as its downstream proteins; up-regulating death inducer-obliterator (DIO-1); down-regulating NF-κB; down-regulating HERG potassium channel; and induction of ROS accumulation.
