Table 1. Distribution of gene polymorphisms and association results for type 2 diabetes.
| Type 2 diabetes patients group | Healthy control group | ΔP | OR (95% CI) (Univariate analysis) | #P | OR (95% CI) (Multivariate analysis) | †P | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency | n | % | n | % | ||||||
| PPAR-γ2 rs1801282 | ||||||||||
| CC | 180 | 91.37 | 180 | 84.91 | 1 | 1 | ||||
| CG | 17 | 8.63 | 32 | 15.09 | 0.044b | 0.531 (0.285–0.991) | 0.047b | 0.515 (0.268–0.990) | 0.047b | |
| PTPRD rs17584499 | ||||||||||
| CC | 145 | 73.60 | 179 | 84.43 | 1 | 1 | ||||
| CT | 49 | 24.87 | 31 | 14.62 | 0.026b | 1.945 (1.194–3.169) | 0.008c | 1.984 (1.135–3.469) | 0.016b | |
| TT | 3 | 1.52 | 2 | 0.94 | ||||||
| Allele frequency | n | % | n | % | ||||||
| PPAR-γ2 rs1801282 | ||||||||||
| C | 377 | 95.69 | 392 | 92.45 | ||||||
| G | 17 | 4.31 | 32 | 7.55 | 0.052 | 0.552 (0.302–1.012) | 0.055 | 0.544 (0.290–1.020) | 0.058 | |
| PTPRD rs17584499 | ||||||||||
| C | 339 | 86.04 | 389 | 91.75 | ||||||
| T | 55 | 13.96 | 35 | 8.25 | 0.009c | 1.793 (1.145–2.806) | 0.011b | 1.904 (1.137–3.189) | 0.014b | |
ΔP values: for comparison between type 2 diabetes patients and healthy control by χ2 test;
#P values and their ORs: for comparison between genotypes by logistic regression analysis in dominant model;
†P values and their ORs: for multivariate analyses after adjusted for age, gender and BMI.
bP<0.05,
cP<0.01.