. Author manuscript; available in PMC: 2014 May 6.

Published in final edited form as: Nat Med. 2014 Feb;20(2):130–138. doi: 10.1038/nm.3457

Table 1.

Summary of studies demonstrating the transmissibility of non-prion protein aggregates

Protein	Type of seed	Seeded aggregation in different model systems
Protein	Type of seed	Non-neuronal cells	Neuronal cells	Mice
Aβ	Synthetic fibrils	Not tested	Not tested	Yes²²
	Mouse brain lysates	Not tested	Not tested	Yes^22,41,72
	Human brain lysates	Not tested	Not tested	Yes⁴¹

Tau	Synthetic fibrils	Yes^17,58	Yes^62,133	Yes¹⁹
	Mouse brain lysates	Not tested	Not tested	Yes¹⁸
	Human brain lysates	Not tested	Not tested	Yes^29,42

α-Syn	Synthetic fibrils	Yes¹³⁴	Yes^15,133	Yes^16,20,21
	Mouse brain lysates	Not tested	Not tested	Yes²⁰
	Human brain lysates	Not tested	Not tested	Yes²¹

TDP-43	Synthetic fibrils	Yes¹³⁵	Not tested	Not tested
TDP-43	Human brain lysates	Not tested	Yes¹³⁶	Not tested

SOD1	Synthetic fibrils	Not tested	Yes⁵⁷	Not tested

PolyQ	Synthetic fibrils	Yes⁵⁶	Not tested	Not tested