Table 1. Main characteristics of all studies included in the meta-analysis.
| First author/year | Country | Ethnicity | Cancer type | SC | XPG Asp1104His (Case/control) | XPF Arg415Gln (Case/control) | HWE | ||||
| Smith [8] 2003 | USA | Caucasian | Breast | HB | NA | NA | NA | 217/236 | 29/32 | 7/0 | Yes |
| Kumar [9] 2003 | Filand | Caucasian | Breast | HB | 108/182 | 96/107 | 16/19 | NA | NA | NA | Yes |
| Jeon [10] 2003 | Korea | Asian | Lung | HB | 58/90 | 164/132 | 88/89 | NA | NA | NA | No |
| Sanyal [11] 2004 | Swede | Caucasian | Bladder | NA | 182/173 | 109/91 | 8/20 | NA | NA | NA | Yes |
| Blankenburg [12] 2005 | German | Caucasian | Melanoma | HB | 184/232 | 100/124 | 9/18 | NA | NA | NA | Yes |
| Weiss [13] 2005 | USA | Mixed | Endometrial | PB | 215/250 | 134/148 | 22/22 | 316/369 | 54/49 | 1/2 | Yes |
| Shen [14] 2005 | China | Asian | Lung | PB | 26/25 | 52/46 | 38/38 | NA | NA | NA | Yes |
| Bigler [15] 2005 | USA | Mixed | Colorectal | PB | 440/353 | 243/226 | 36/37 | NA | NA | NA | Yes |
| Sakiyama [16] 2005 | Japan | Asian | Lung | HB | 300/228 | 500/333 | 202/124 | NA | NA | NA | Yes |
| Cui [17] 2006 | USA | Mixed | Lung | PB | 244/468 | 212/356 | 41/78 | NA | NA | NA | Yes |
| Cui [17] 2006 | USA | Mixed | Multiple | PB | 214/474 | 194/357 | 35/80 | NA | NA | NA | Yes |
| Zienolddiny [18] 2006 | Norway | Caucasian | Lung | HB | NA | NA | NA | 195/178 | 26/21 | 3/1 | Yes |
| Millikan [19] 2006 | USA | Caucasian | Melanoma | PB | 731/1513 | 389/780 | 73/115 | 1026/2073 | 173/360 | 9/12 | Yes |
| Mechanic [20] 2006 | USA | Caucasian | Breast | PB | 771/661 | 409/412 | 69/60 | 1049/980 | 185/150 | 12/3 | Yes |
| Mechanic [20] 2006 | USA | African | Breast | PB | 231/231 | 387/320 | 139/123 | 738/642 | 18/31 | 1/0 | Yes |
| Huang [21] 2006 | USA | Mixed | Colorectal | PB | 407/403 | 243/265 | 29/29 | 624/623 | 78/86 | 1/7 | Yes |
| García-Closas [22] 2006 | Spain | Caucasian | Bladder | HB | 629/607 | 434/445 | 78/84 | 885/824 | 203/182 | 14/19 | Yes |
| Moreno [23] 2006 | Spain | Caucasian | Colorectal | HB | NA | NA | NA | 282/257 | 71/61 | 7/5 | Yes |
| Shen [24] 2006 | USA | Mixed | NHL | PB | 260/352 | 170/169 | 34/29 | NA | NA | NA | Yes |
| Shen [25] 2006 | USA | Mixed | Breast | FB | 83/82 | 63/62 | 8/7 | NA | NA | NA | Yes |
| Wen [26] 2006 | China | Asian | HNC | PB | 55/129 | 81/296 | 39/100 | NA | NA | NA | No |
| Li [27] 2006 | USA | Caucasian | Melanoma | HB | 373/370 | 206/206 | 23/27 | NA | NA | NA | Yes |
| Wu [28] 2006 | USA | Caucasian | Bladder | HB | 364/371 | 225/211 | 26/18 | NA | NA | NA | Yes |
| Sugimura [29] 2006 | Japan | Asian | HNC | HB | 20/52 | 59/112 | 43/77 | NA | NA | NA | Yes |
| Thirumaran [30] 2006 | Multiple | Caucasian | Skin | HB | 325/330 | 172/173 | 32/30 | NA | NA | NA | Yes |
| Hill [31] 2006 | Multiple | Mixed | NHL | PB | 599/521 | 425/331 | 77/71 | NA | NA | NA | Yes |
| Crew [32] 2007 | USA | Mixed | Breast | PB | 562/571 | 371/409 | 66/71 | 859/888 | 156/167 | 3/10 | Yes |
| Jorgensen [33] 2007 | USA | Caucasian | Breast | PB | 159/165 | 93/95 | 12/15 | 221/231 | 37/43 | 1/1 | Yes |
| Romanowicz [34] 2007 | Poland | Caucasian | Breast | NA | NA | NA | NA | 31/21 | 40/48 | 29/37 | Yes |
| Povey [35] 2007 | UK | Caucasian | Melanoma | PB | 314/252 | 169/162 | 24/27 | NA | NA | NA | Yes |
| Wang [36] 2007 | USA | Mixed | Skin | HB | 146/200 | 89/119 | 11/10 | NA | NA | NA | Yes |
| Shen [37] 2007 | Australia | Caucasian | NHL | PB | 340/294 | 170/163 | 30/27 | NA | NA | NA | Yes |
| McWilliams [38] 2008 | USA | Mixed | Pancreatic | HB | NA | NA | NA | 411/481 | 59/111 | 0/4 | Yes |
| Hooker [39] 2008 | USA | African | Prostate | HB | 74/100 | 119/141 | 61/60 | NA | NA | NA | Yes |
| Smith [40] 2008 | USA | Caucasian | Breast | HB | 195/256 | 113/124 | 12/28 | 278/358 | 39/47 | 7/1 | Yes |
| Smith [40] 2008 | USA | African | Breast | HB | 13/18 | 32/37 | 7/20 | 51/73 | 2/2 | 0/0 | Yes |
| Chang [41] 2008 | USA | Hispanic | Lung | HB | 60/138 | 44/127 | 9/34 | 97/267 | 16/31 | 0/1 | Yes |
| Chang [41] 2008 | USA | African | Lung | HB | 68/93 | 119/138 | 68/49 | NA | NA | NA | Yes |
| Rajaraman [42] 2008 | USA | Caucasian | Breast | PB | 482/674 | 288/352 | 49/53 | 714/922 | 124/147 | Yes | |
| Frei˘din [43] 2008 | Russia | Caucasian | Multiple | HB | 38/92 | 12/36 | 2/12 | NA | NA | NA | No |
| Hung [44] 2008 | Multiple | Mixed | Lung | NA | 1852/2485 | 1155/1510 | 209/286 | 2201/2208 | 306/390 | 13/21 | No for Asp1104His |
| He [45] 2008 | China | Asian | Cervical | HB | 35/53 | 94/80 | 71/67 | NA | NA | NA | No |
| Pardini [46] 2008 | Czech | Caucasian | Colorectal | HB | 334/356 | 177/153 | 21/23 | NA | NA | NA | Yes |
| Joshi [47] 2009 | USA | Caucasian | Colorectal | FB | 183/213 | 125/148 | 265/313 | 40/47 | NA | ||
| El-Zein [48] 2009 | USA | Mixed | NHL | HB | 104/127 | 78/80 | 16/12 | NA | NA | NA | Yes |
| Wen [49] 2009 | China | Asian | Bladder | HB | 15/45 | 57/233 | NA | NA | NA | NA | |
| Narter [50] 2009 | Turkey | Caucasian | Bladder | NA | 25/18 | 28/19 | 3/3 | NA | NA | NA | Yes |
| Abbasi [51] 2009 | German | Caucasian | HNC | PB | 137/380 | 103/230 | 8/37 | 203/554 | 44/90 | 1/3 | Yes |
| Hussain [52] 2009 | China | Asian | Gastric | PB | 38/90 | 104/180 | 39/91 | NA | NA | NA | Yes |
| McKean-Cowdin [53] 2009 | USA | Caucasian | Glioma | PB | 499/989 | 348/657 | 157/311 | NA | NA | NA | No |
| Pan [54] 2009 | USA | Caucasian | esophageal | HB | 222/287 | 145/155 | 15/15 | NA | NA | NA | Yes |
| Han [55] 2009 | USA | Caucasian | Breast | PB | 142/285 | 80/167 | 17/20 | 200/401 | 38/69 | 0/2 | Yes |
| Liu [56] 2009 | USA | Caucasian | Glioma | PB | 353/351 | 20/13 | NA | NA | NA | NA | |
| Agalliu [57] 2010 | USA | Caucasian | Prostate | PB | NA | NA | NA | 1025/1012 | 183/202 | 13/5 | Yes |
| Agalliu [57] 2010 | USA | African | Prostate | PB | NA | NA | NA | 136/78 | 8/3 | 0/0 | Yes |
| Rajaraman [58] 2010 | USA | Caucasian | Glioma | HB | 206/286 | 123/156 | 13/26 | 280/405 | 56/62 | 1/4 | Yes |
| Ming-Shiean [59] 2010 | China | Asian | Breast | HB | 134/159 | 191/243 | 76/129 | NA | NA | NA | Yes |
| Li [60] 2010 | China | Asian | Liver | HB | 174/151 | 233/265 | 93/91 | NA | NA | NA | Yes |
| Canbay [61] 2010 | Turkey | Caucasian | Gastric | NA | 25/148 | 12/83 | 3/16 | NA | NA | NA | Yes |
| Figl [62] 2010 | Multiple | Caucasian | Melanoma | HB | 703/725 | 409/465 | 74/84 | NA | NA | NA | Yes |
| Rouissi [63] 2011 | Tunis | African | Bladder | HB | 95/87 | 70/86 | 28/20 | NA | NA | NA | Yes |
| Liu [64] 2011 | China | Asian | Colorectal | HB | 233/329 | 603/537 | 192/219 | NA | NA | NA | Yes |
| Canbay [65] 2011 | Turkey | Caucasian | Colorectal | NA | 43/148 | 34/83 | 2/16 | NA | NA | NA | Yes |
| Gonçalves [66] 2011 | Braze | Caucasian | Melanoma | HB | 105/109 | 77/74 | 10/25 | NA | NA | NA | Yes |
| Ibarrola-Villava [67] 2011 | Spain | Caucasian | Melanoma | HB | 412/242 | 222/140 | 50/24 | 560/316 | 117/87 | 7/3 | Yes |
| Doherty [68] 2011 | USA | Mixed | Endometrial | PB | 418/408 | 254/248 | 42/47 | 593/620 | 107/89 | 3/5 | Yes |
| Biason [69] 2011 | Italy | Caucasian | Osteosarcoma | HB | 75/141 | 39/94 | 16/15 | NA | NA | NA | Yes |
| Krupa [70] 2011 | Poland | Caucasian | HNC | HB | NA | NA | NA | 221/224 | 26/29 | 6/0 | Yes |
| Yu [71] 2011 | USA | Caucasian | HNC | HB | NA | NA | NA | 837/829 | 195/209 | 8/8 | Yes |
| Ma [72] 2012 | USA | Caucasian | HNC | HB | 648/654 | 359/350 | 52/62 | NA | NA | NA | Yes |
| Gil [73] 2012 | Poland | Caucasian | Colorectal | HB | 86/64 | 35/31 | 11/5 | 119/83 | 14/15 | 0/0 | Yes |
| Berhane [74] 2012 | India | Asian | Prostate | HB | 58/128 | 72/146 | 20/26 | NA | NA | NA | Yes |
| Paszkowska-Szczur [75] 2013 | Poland | Caucasian | Melanoma | PB | 412/869 | 200/404 | 28/85 | NA | NA | NA | Yes |
| Wen [80] 2013 | China | Asian | Bladder | HB | 40/172 | 46/62 | 26/44 | NA | NA | NA | No |
| Wang [81] 2013 | China | Asian | Glioma | HB | NA | NA | NA | 265/609 | 59/36 | 6/7 | No |
| Santos [82] 2013 | Portugal | Caucasian | HNC | HB | 51/106 | 50/85 | 4/21 | 77/168 | 23/38 | 2/4 | No |
| Cheng [83] 2013 | China | Asian | Glioma | HB | NA | NA | NA | 149/182 | 41/43 | 17/11 | Yes |
HNC head and neck cancer, PB population-based study, HB hospital-based study.