Table 1.

Mean systemic arterial pressure (MAP) and heart rate (HR) in young (n = 5) and aged (n = 5–6) wild type (WT), heterozygotes (Hemi), and transgenic sickle-cell (Sickle) mice

	MAP (mm Hg)	HR (beats/min)
Young WT	83.8 ± 4.7	585.8 ± 12.7
Young Hemi	85.8 ± 2.6	579.5 ± 10.2
Young Sickle	81.5 ± 5.3	582.8 ± 9.0
Aged WT	95.7 ± 5.5*	584.4 ± 21.1
Aged Hemi	96.7 ± 5.5**	587.3 ± 13.9
Aged Sickle	106.8 ± 2.7***;****	592.5 ± 8.3

^*P = 0.0061 young vs. aged WT MAP;

^**P = 0.0035 young vs. aged Hemi MAP;

^***P ≤ 0.0001 young vs. aged Sickle MAP;

^****P = 0.0049 aged sickle vs. aged WT and Hemi MAP.