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. 2014 May 6;9(5):e92475. doi: 10.1371/journal.pone.0092475

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© 2014 Biton et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Computer simulation and Experimental TPM results showing a DNA molecule of 1632(Case B) , and yielding 600 bp Lac repressor-induced loops; and (Case C) , and yielding 900 bp Lac repressor-induced loops. The bead radius for both cases is 160 nm. The figure shows the joint distribution of RMS projected distance between the center of the bead attached to the end for which to the DNA end that is attached to the plate. Each single RMS value in the experimental results (blue) was calculated using a time window of 8 s. The simulation results (red) were calculated from the probability density functions given in Figures 12B, and 12C and our calculated looping -factors (See Table 2).

Inline graphic — Computer simulation and Experimental TPM results showing a DNA molecule of 1632(Case B) , and yielding 600 bp Lac repressor-induced loops; and (Case C) , and yielding 900 bp Lac repressor-induced loops. The bead radius for both cases is 160 nm. The figure shows the joint distribution of RMS projected distance between the center of the bead attached to the end for which to the DNA end that is attached to the plate. Each single RMS value in the experimental results (blue) was calculated using a time window of 8 s. The simulation results (red) were calculated from the probability density functions given in Figures 12B, and 12C and our calculated looping -factors (See Table 2).