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. 2014 May 6;9(5):e95908. doi: 10.1371/journal.pone.0095908

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© 2014 Halabi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) In rats pretreated with 10% Tween 20 (negative control) normal tissue has intact surface mucosal epithelium. (b). Rats pre-treated with 10% Tween 20 (ulcer control) have severe disruption of the surface epithelium and necrotic lesions that penetrate deeply into the mucosa (c) Rats pretreated with Omeprazole (20 mg/kg) have mild disruption of the surface epithelium mucosa, and there is a reduction in submucosal edema and leucocyte infiltration. (d) Rats pre-treated with ETHAB (5 mg/kg) have moderate disruption of the surface epithelium with edema and leucocyte infiltration of the submucosal layer. (e) Rats pretreated with ETHAB (10 mg/kg) have a mild to moderate disruption of the surface epithelium and a reduction in submucosal edema. (f) Rats pre-treated with ETHAB (20 mg/kg) have mild disruption of the surface epithelium (H&E staining; 10×).