. 2014 May 6;9(5):e96003. doi: 10.1371/journal.pone.0096003

Table 1. Demographic characteristics and lower leg calcification scores (LLAC) in patients with pseudoxanthoma elasticum (PXE) without (PAD−) or with (PAD+) peripheral arterial disease and controls.

	PXE_PAD− (n = 31)		PXE_PAD+ (n = 40)			overall PXE		Controls (n = 30)		P (chi2)
Gender (m/f)	6/25		15/25			21/50		9/21		0.263
Hypertension (%)	6		40			25		11		0.002
Dyslipidemia (%)	6		47			30		14		0.000
Smoking (%)	26		27			27		18		0.637
Stroke (%)	0		20			11		0		0.001
Myocardial infarction (%)	3		15			10		0		0.048
	mean	SD	mean	SD	PAD− vsPAD+	mean	SD	mean	SD	Ctrl vs PXE	Ctrl vs PXE_PAD−	Ctrl vs PXE_PAD+
Age (years)	43	13	52	13	0.006	48	14	43	14	0.007		0.011
BMI (kg/m²)	25	5	26	5		26	5	25	5	0.225
Cardiovascular risk score (%)	1.5	2.1	3.5	3.7	0.002	2.6	3.2	2.3	4.2	0.003		0.008
Systolic ABP (mmHg)	118	11	125	15	0.012	122	14	126	17	0.034	0.05
Diastolic ABP (mmHg)	73	10	73	11		73	10	77	14	0.025
Ankle-Brachial Index	1.03	0.08	0.69	0.14		0.84	0.20	1.04	0.10	0.001
Blood glucose (mmol.L⁻¹)	4.87	0.58	5.19	0.85		5.05	0.76	5.18	0.67	0.089
Total Cholesterol (mmol.L⁻¹)	4.82	0.96	4.94	0.83		4.89	0.89	5.36	0.96	0.168
LDL (mmol.L⁻¹)	2.88	0.83	2.93	0.78		2.91	0.80	3.12	0.91	0.675
HBA1C (%)	5.7	0.4	5.7	0.4		5.7	0.4	5.6	0.3	0.498
Arterial calcification (AC) scores
LLAC (HU)	2998	6145	9355	16137	0.003	6658	13188	335	879	<0.0001	0.006	<0.0001
Femoral AC (HU.mm⁻¹)	5.08	12.04	16.93	25.69	<0.001	11.91	21.70	0.88	2.61	<0.0001		<0.0001
Popliteal AC (HU.mm⁻¹)	1.63	5.11	5.03	15.01	0.045	3.59	11.91	0.10	0.53	<0.0001		<0.0001
Sub-popliteal AC (HU.mm⁻¹)	3.38	7.00	9.44	22.05	0.025	6.87	17.50	0.15	0.40	<0.0001	<0.001	<0.0001