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Timeline of FDA approvals of HER2-targeted breast cancer therapies and conduct of the registHER and systHERs observational studies. BC, breast cancer; FDA, US Food and Drug Administration; HER2, human epidermal growth factor receptor 2; MBC, metastatic breast cancer; OS, overall survival; SystHERs, Systematic Therapies for HER2-positive Metastatic Breast Cancer Study; T-DMI, trastuzumab emtansine.
