Figure 2. Multiple cytoskeletal pathways suppress activated CDC-42 in PDE neurons. (A) Quantitation of PDE defects. lqIs37 is Posm-6::CDC-42(G12V) activated CDC-42 transgene. The Y-axis denotes the genotype and the X-axis represents the percentage of ectopic lamellipodia formation. “M+” denotes that the animals had wild-type maternal contribution. The number of axons scored > 100 for each genotype. p < 0.0004 as determined by Fisher Exact Analysis. The error bars represent 2x SEP. (B) A diagram depicting CDC-42 signaling to the Arp2/3 complex based on genetic results in this study and in other work.