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. 2014 May 6;9(5):e96585. doi: 10.1371/journal.pone.0096585

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© 2014 Brisson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A1) Comparison of regional responses to OGD in terms of AD strength (peak LT increases) and subsequent dendritic injury (maximal LT decreases) shows more swelling and subsequent injury by higher brain regions compared to brainstem nuclei. The exception is superior colliculus, which displays injury similar to higher gray matter, possibly because it has been a prominent surface structure throughout vertebrate evolution until recently. A2) The means of peak LT values displayed by higher and lower regions (excluding SupCo) were collapsed and compared with an independent samples t-test and found to be significantly different [t(58) = 3.6, p<0.001]. B1) Propagation speed of the AD front is faster in higher brain gray matter than brainstem nuclei, again with the exception of superior colliculus. B2). The means of the rate (mm/min) displayed by higher and lower regions (excluding SupCo) were collapsed and compared with an independent samples t-test and found to be significantly different [t(36.7) = 6.02,p<0.001].