Table 1. Whole-cell recording parameters from ‘higher’ CA1 and striatal neurons (n = 36) compared to brainstem neurons (n = 65) responding to 10 minutes of oxygen/glucose deprivation.
| Neuron Type | Rmp (mV) | Rmp Post-OGD (mV) | % Rmp Recov. | Max Depol. (mV) | % AP Ampl. Recov. | Rin (MΩ) | % Rin Recov. | AD Onset (sec) |
| CA1 pyramidal (n = 9) | −63±2.5 | −6±7.4 | 10±11.8 | Near zero | No recovery | 99±17.7 | No recovery | 343±84 |
| CA1 pyramidal (n = 17) [37] | −62±3.0 | −9±4.6 | No recovery | Near zero | No recovery | 47±8.4 | No recovery | 318±78 |
| Striatal (n = 10) | −70±3.0 | −20±16.9 | 29±23.6 | Near zero | No recovery | 55±17.6 | No recovery | 287±23 |
| Locus Ceruleus (n = 8) | −48±2.8 | −40±10.1 | 82±19.4 | −4±4.6 | 83±15.0 | 219±88 | 100±11 | 301±60 |
| Mesencephalic (n = 14) | −53±2.3 | −50±6.0 | 93±10.2 | −42±11.5 | 95±8.1 | 48±41 | 86±23 | 301±60 |
| Dorsal nuc. tractus solitarius (n = 31) | −48±4.5 | −36±11.6 | 75±23 | −10±7.8 | 73±13.4 | 785±470 | 57±30 | 322±87 |
| Dorsal motor nucleus of vagus (n = 12) | −46±1.4 | N/A | N/A | −1±1.4 | N/A | 278 | N/A | ∼322 |
All neurons were exposed to 10 minutes OGD except 16 of the 31 dNTS neurons which underwent 15 minutes of OGD. Post-OGD measurements made 15–30 minutes following return to control aCSF. More details of the electrophysiological properties of each neuron as well as the properties of newly acquired brainstem neurons recorded in post-OGD slices can be found at http://hdl.handle.net/1974/7578 [36]. Abbreviations: Rmp, resting membrane potential; Max Depol., maximum depolarization of anoxic depolarization; AP Ampl., action potential amplitude; Rin, whole-cell input resistance. % Rmp recovery was calculated before correcting for a +14 mV junction potential.