Figure 4. Aortic myography.

Wild type (WT, open symbols, N = 9) and heterozygous F508del (closed symbols, N = 8) aortic constriction to KCl was assessed in the presence of buffer alone (A), CFTR inhibition (B, CFTRinh-172), or IP₃R antagonism (C, 2-APB). After rinsing the arterial segments, the responses were then assessed to cumulative concentrations of noradrenaline (NA). In buffer alone, F508del aorta had attenuated constriction to NA (D). This was blocked by preincubation of the aortic segments in either CFTRinh-172 (E), or 2-APB (F). *P<0.05 versus WT.