. 2014 Feb 26;6(3):689–696. doi: 10.4161/mabs.28254

Table 2. Tissue AUC_0–7 (day*%ID/mL) for anti-gD variants.

Variant	Label	Plasma	Lungs	Liver	Kidney	Heart	Spleen	Stomach	Large Intestine	Small Intestine	Brain	Muscle	Skin
IgG1 WT	¹²⁵I	164 ± 5.38	21.5 ± 1.20	15.5 ± 0.575	15.4 ± 2.14	15.5 ± 0.692	14.6 ± 0.340	8.01 ± 0.425	7.09 ± 0.591	6.36 ± 0.268	1.55 ± 0.0900	5.43 ± 0.0946	21.5 ± 1.53
IgG1 WT	¹¹¹In	182 ± 2.76	28.3 ± 1.34	37.2 ± 1.60	32.1 ± 2.45	18.5 ± 0.758	31.6 ± 2.00	9.79 ± 0.575	10.1 ± 0.649	9.16 ± 0.502	2.09 ± 0.0923	6.85 ± 0.243	26.6 ± 1.15
IgG1 FcRn⁺	¹²⁵I	169 ± 14.0	22.8 ± 3.30	22.1 ± 1.30*	16.1 ± 2.10	16.3 ± 1.25	18.8 ± 1.32*	8.18 ± 0.401	6.92 ± 0.636	6.55 ± 0.626	2.00 ± 0.122*	5.72 ± 0.353	25.2 ± 1.82
IgG1 FcRn⁺	¹¹¹In	182 ± 9.97	28.3 ± 2.85	37.8 ± 1.48	31.2 ± 2.02	18.3 ± 1.09	38.1 ± 1.95*	9.63 ± 0.323	10.0 ± 0.628	9.35 ± 0.971	2.59 ± 0.139*	6.67 ± 0.449*	30.7 ± 1.26*
IgG1 FcRn^-	¹²⁵I	43.1 ± 1.16*	6.63 ± 0.500*	3.77 ± 0.220*	5.46 ± 0.131*	4.46 ± 0.407*	4.60 ± 0.544*	3.63 ± 0.100*	1.76 ± 0.132*	2.00 ± 0.104*	0.58 ± 0.0485*	1.52 ± 0.124*	5.89 ± 0.490*
IgG1 FcRn^-	¹¹¹In	94.5 ± 1.46*	17.8 ± 0.821*	60.0 ± 2.41*	25.6 ± 1.02*	16.8 ± 0.923	53.3 ± 7.16*	7.58 ± 0.278*	11.1 ± 1.00	10.7 ± 0.598*	1.30 ± 0.121*	4.01 ± 0.423*	22.6 ± 3.41

Significant (P < 0.05) differences by unpaired t test are indicated by asterisks and are relative to IgG WT for the corresponding radionuclide.

Table 2. Tissue AUC0–7 (day*%ID/mL) for anti-gD variants.