Table 1. Antibodies selected against WEEV. The most similar human germline genes were identified by IMGT (www.IMGT.org).
| Antibody clone | Antibody gene library | VH | VL | |||||
|---|---|---|---|---|---|---|---|---|
| V | D | J | Germinality index | V | J | Germinality index | ||
| ToR68–2C3 | macaque 1 | IGHV1–2*02 | IGHD3–9*01 | IGHJ5*02 | 83.5% | IGKV7–3*01 | IGKJ1*01 | 73.0% |
| ToR68–2E9 | macaque 1 | IGHV3–43*02 | IGHD6–13*01 | IGHJ5*02 | 87.9% | IGKV1–17*01 | IGKJ2*03 | 88.8% |
| ToR68–3G2 | macaque 1 | IGHV4–4*07 | IGHD2–21*02 | IGHJ4*02 | 93.4% | IGKV3D-15*01 | IGKJ1*01 | 86.5% |
| ToR69–3A2 | macaque 2 | IGHV3–15*08 | IGHD3–22*01 | IGHJ5*02 | 89.0% | IGKV1–13*02 | IGKJ1*01 | 91.0% |
| 10B5 | ref. 40 | IGHV1–46*01 | IGHD4–23*01 | IGHJ4*03 | 65.9% | IGKV1–37*01 | IGKJ4*02 | 68.5% |
The germinality index describes the similarity of the antibodies to the corresponding human germline genes identified by IMGT/V-Quest in terms of the percent identity of the VH or VL framework region.