Table 2.

Isolated fungal pathogens and response to antifungal treatment in patients with febrile neutropenia

Patient	Age	Sex	Hematologic malignancy	Sample	Isolated fungal pathogen	Antifungal resistance	Previous azole exposure	Empirical antifungal treatment before identification	Treatment modification	Outcome
1	32	Male	AML	Blood	Candida parapsilosis	VOR, FLC	+	CAS	–	Survived
				Blood	Candida parapsilosis	VOR, FLC	+	CAS	–	Survived
				Blood	Candida glabrata	FLC	+	L-AmB	Central line removed	Survived
2	24	Male	ALL	Sputum	Candida albicans	–	−	VOR	–	Survived
3	51	Male	AML	Blood	Candida parapsilosis	VOR, FLC	+	CAS	Central line removed	Survived
				Blood, wound	Candida parapsilosis	VOR, FLC	+	VOR	From VOR to AmB	Died
4	32	Male	AML	Blood	Candida parapsilosis	VOR, FLC	+	CAS	–	Survived
				Blood	Candida parapsilosis	VOR, FLC	+	VOR	L-AmB	Survived
5	52	Female	ALL	Blood	Geotrichum capitatum	FLC, ITR	−	CAS	Central line removed	Survived
				Blood	Geotrichum capitatum	FLC, ITR	+	VOR	–	Died
6	59	Female	AML	Urine, sputum	Candida kefyr	FLC	+	L-AmB	–	Survived
7	60	Female	ALL	Blood	Candida albicans	VOR, ITR, FLC	−	CAS	–	Survived
8	21	Female	Aplastic anemia	Blood	Candida albicans		−	CAS	–	Survived
9	33	Male	AML	Blood	Geotrichum capitatum	FLC	−	VOR	Central line removed	Survived
10	60	Female	AML	Sputum	Candida kefyr	FLC, ITR	+	VOR	–	Survived
				Sputum	Candida kefyr	FLC, ITR	+	VOR		Died
11	58	Female	CLL + Burkitt’s lymphoma	Sputum	Aspergillus fumigatus		−	CAS	–	Survived
12	59	Female	AML	BAL	Aspergillus fumigatus		−	VOR	–	Survived
				Sputum	Aspergillus fumigatus		+	L-AmB	–	Survived
13	55	Female	AML	Blood	Trichosporon asahii	AmB	+	CAS	Central line removed	Died
14	63	Female	AML	Blood	Trichosporon asahii	AmB	+	L-AmB	From AmB to VOR, central line removed	Died
15	45	Female	AML	Blood	Trichosporon asahii	AmB, ITR	−	CAS	Empirically switched to VOR	Died
16	50	Male	AML + lung cancer	Blood	Candida parapsilosis		+	VOR	From VOR to AmB, central line removed	Survived
				Blood	Candida albicans	–	+	VOR	–	Survived
17	62	Female	AML	Blood, sputum	Candida parapsilosis		+	VOR	From VOR to CAS, central line removed	Died
18	61	Male	AML	Blood, urine	Candida albicans		+			Died
19	73	Female	NHL	Blood, central line	Candida albicans		+	L-AmB	Central line removed	Survived
20	35	Male	AML	Blood	Candida albicans		+	CAS		Survived
21	44	Female	ALL	Blood	Candida albicans		+	L-AmB		Survived
22	63	Female	AML	Blood	Candida krusei		+	VOR	–	Survived
23	51	Female	AML	Blood	Candida albicans	–	+	VOR	–	Survived

Abbreviations: AmB, amphotericin B; ALL, acute lymphocytic leukemia; AML, acute myeloblastic leukemia; BAL, bronchoalveolar lavage; CAS, caspofungin; CLL, chronic lymphocytic leukemia; FLC, fluconazole; ITR, Itiaconazole; L-AmB, liposomal amphotericin B; NHL, non-Hodgkin lymphoma; VOR, voriconazole.