Table 2.
Unadjusted hazard rate ratios for baseline patient characteristics associated with death during TB treatment among patients in the state of Georgia, 2009–2012
| Patient characteristic (at TB treatment start) |
Died N=83/1238 (6.7) Died/N (%) |
cHR (95% CI) |
|---|---|---|
| Diabetes mellitus | ||
| No | 66/1089 (6.1) | 1.00 |
| Yes | 17/149 (11.4) | 1.88 (1.10, 3.20) |
| Age (years) | ||
| 16–34 | 6/402 (1.5) | 1.00 |
| 35–44 | 9/213 (4.2) | 2.78 (0.99, 7.8) |
| 45–54 | 19/276 (6.9) | 4.58 (1.83,11.48) |
| ≥55 | 49/347 (14.1) | 10.24 (4.39, 23.92) |
| Sex | ||
| Female | 14/414 (3.4) | 1.00 |
| Male | 69/824 (8.4) | 2.55 (1.44, 4.53) |
| Race/ethnicity | ||
| White | 20/194 (10.3) | 1.00 |
| NH Black | 54/592 (9.1) | 0.85 (0.51, 1.42) |
| NH Asian | 4/220 (1.8) | 0.17 (0.06, 0.49) |
| Hispanic | 5/226 (2.2) | 0.21 (0.08, 0.56) |
| Occupation | ||
| Employed | 11/492 (2.2) | 1.00 |
| Unemployed | 34/479 (7.1) | 3.17 (1.61, 6.26) |
| Retired | 24/124 (19.4) | 9.87 (4.83, 20.16) |
| Other/unknown | 14/143 (9.8) | 4.84 (2.20,10.66) |
| Foreign born | ||
| No | 69/669 (10.3) | 1.00 |
| Yes | 14/568 (2.5) | 0.24 (0.13, 0.42) |
| Recent homeless | ||
| No | 75/1111 (6.8) | 1.00 |
| Yes | 7/124 (5.7) | 0.80 (0.37, 1.74) |
| Currently in correctional facility | ||
| No | 81/1132 (7.2) | 1.00 |
| Yes | 1/103 (1.0) | 0.14 (0.02, 1.03) |
| Heavy alcohol use | ||
| No/unknown | 65/1047 (6.2) | 1.00 |
| Yes | 18/191 (9.4) | 1.51 (0.90, 2.55) |
| Drug use | ||
| No | 73/1113 (6.6) | 1.00 |
| Yes | 6/117 (5.1) | 0.73 (0.32, 1.68) |
| End stage renal disease | ||
| No | 75/1206 (6.2) | 1.00 |
| Yes | 8/32 (25.0) | 4.21 (2.03, 8.73) |
| HIV serologic status | ||
| Negative/unknown | 68/1098 (6.2) | 1.00 |
| Positive | 15/140 (10.7) | 1.59 (0.90, 2.79) |
| AFB sputum smear status | ||
| Negative | 33/655 (5.0) | 1.00 |
| Positive | 35/498 (7.0) | 1.40 (0.87, 2.25) |
| Unknown | 15/85 (17.7) | 3.74 (2.03, 6.89) |
| Baseline culture | ||
| Negative/unknown | 12/298 (4.0) | 1.00 |
| Positive | 71/940 (7.6) | 1.86 (1.01, 3.43) |
| TB site of disease | ||
| Pulmonary only | 56/913 (6.1) | 1.00 |
| Pulmonary and extra-pulmonary | 11/105 (10.5) | 1.67 (0.87, 3.18) |
| Extra-pulmonary only | 16/220 (7.3) | 1.09 (0.63, 1.91) |
| Previous TB treatment | ||
| No | 78/1167 (6.7) | 1.00 |
| Yes | 4/70 (5.7) | 0.86 (0.31, 2.34) |
| Cavitary lung disease on chest radiograph at time of TB diagnosis | ||
| No | 54/780 (6.9) | 1.00 |
| Yes | 28/427 (6.6) | 0.95 (0.60, 1.51) |
| Miliary/Disseminated TB | ||
| No | 78/1187 (6.6) | 1.00 |
| Yes | 5/51 (9.8) | 1.51 (0.61, 3.72) |
| Drug Susceptibility | ||
| None to RIF or INH | 59/827 (7.1) | 1.00 |
| Single Drug (RIF or INH) | 7/96 (7.3) | 0.97 (0.44, 2.13) |
| MDR-TB | 1/6 (16.7) | 1.86 (0.26, 13.57) |
| Unavailable | 16/309 (5.2) | 0.73 (0.42, 1.27) |
Abbreviations: cHR-crude hazard ratio; CI-confidence interval; STD-standard deviation; IQR-interquartile range; NH-Non-Hispanic; RIF-Rifampin; INH-Isoniazid; AFB-acid fast bacilli; MDR-multi-drug resistant (resistance to at least both INH and RIF)