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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Nucl Med. 2014 Mar 20;55(5):759–764. doi: 10.2967/jnumed.113.132647

TABLE 2.

Association of type 2 diabetes with abnormal FDG-PET ratioa in AD signature meta-ROI

Odds ratios (95% CI): column headings represent covariates included in each model
Age and Sex Education APOE ε4 Glucose Cognition Full model 1b Full model 2b
Total sample
OR (95% CI) 2.24 (1.54, 3.27) 2.28 (1.56, 3.33) 2.26 (1.55, 3.30) 1.73 (1.13, 2.63) 2.17 (1.48, 3.18) 1.78 1.17, 2.72) 1.69 (1.10, 2.60)
P value <0.001 <0.001 <0.001 .01 <0.001 0.008 0.02
Cognitively normal
OR (95% CI) 2.21 (1.42, 3.43) 2.22 (1.43, 3.45) 2.20 (1.42, 3.41) 1.50 (0.91, 2.49) N/A 1.50 (0.91, 2.49) N/A
P value 0.0004 0.0004 0.0005 0.12 0.12
MCI
OR (95% CI) 2.02 (0.93, 4.41) 2.22 (1.00, 4.92) 2.31 (1.03, 5.18) 1.96 (0.85, 4.51) N/A 2.62 (1.08, 6.38) N/A
P value 0.08 0.05 0.04 0.11 0.03

Abbreviations: AD = Alzheimer’s disease; MCI = mild cognitive impairment.

a

AD signature meta-ROI FDG ratio < 1.31.

b

All models include adjustment for age and sex; each column shows the variable added separately to a model with age and sex. Full model 1 is adjusted for age, sex, education, APOE ε4 allele, and glucose level. Full model 2 includes variables in full model 1 and cognition (MCI or normal cognition).