TABLE 2.
Odds ratios (95% CI): column headings represent covariates included in each model | |||||||
---|---|---|---|---|---|---|---|
Age and Sex | Education | APOE ε4 | Glucose | Cognition | Full model 1b | Full model 2b | |
Total sample | |||||||
OR (95% CI) | 2.24 (1.54, 3.27) | 2.28 (1.56, 3.33) | 2.26 (1.55, 3.30) | 1.73 (1.13, 2.63) | 2.17 (1.48, 3.18) | 1.78 1.17, 2.72) | 1.69 (1.10, 2.60) |
P value | <0.001 | <0.001 | <0.001 | .01 | <0.001 | 0.008 | 0.02 |
Cognitively normal | |||||||
OR (95% CI) | 2.21 (1.42, 3.43) | 2.22 (1.43, 3.45) | 2.20 (1.42, 3.41) | 1.50 (0.91, 2.49) | N/A | 1.50 (0.91, 2.49) | N/A |
P value | 0.0004 | 0.0004 | 0.0005 | 0.12 | 0.12 | ||
MCI | |||||||
OR (95% CI) | 2.02 (0.93, 4.41) | 2.22 (1.00, 4.92) | 2.31 (1.03, 5.18) | 1.96 (0.85, 4.51) | N/A | 2.62 (1.08, 6.38) | N/A |
P value | 0.08 | 0.05 | 0.04 | 0.11 | 0.03 |
Abbreviations: AD = Alzheimer’s disease; MCI = mild cognitive impairment.
AD signature meta-ROI FDG ratio < 1.31.
All models include adjustment for age and sex; each column shows the variable added separately to a model with age and sex. Full model 1 is adjusted for age, sex, education, APOE ε4 allele, and glucose level. Full model 2 includes variables in full model 1 and cognition (MCI or normal cognition).