Table III.
Statistics from region-based thickness cortical thickness in 1,010 subjects. Brain measurements were averaged across left and right hemispheres prior to genetic analysis. Significant p-values are reported in scientific notation. A negative (positive) β for sex indicates the value of the phenotypic measure was generally smaller in females (males).
| Gyrus/Region Thickness | h2 (p-value) | Age β (p-value) | Age2 β (p-value) | Sex β (p-value) | Age × Sex β (p-value) | Age2 × Sex β (p-value) |
|---|---|---|---|---|---|---|
| Superior frontal | 0.44 (3.0E-12) | −4.0E-02 (1.3E-52) | 1.4E-04 (0.30) | 5.1E-02 (0.46) | 5.0E-03 (0.13) | 3.3E-04 (0.064) |
| Rostral middlefrontal | 0.39 (7.3E-11) | −2.9E-02 (2.3E-24) | −3.9E-05 (0.79) | −1.8E-01 (2.0E-02) | 5.6E-03 (0.13) | 3.7E-04 (0.068) |
| Caudal middle frontal | 0.53 (1.9E-16) | −3.9E-02 (3.6E-47) | 2.4E-04 (0.077) | 3.4E-02 (0.63) | 1.1E-02 (2.1E-03) | −2.7E-05 (0.88) |
| Pars opercularis | 0.38 (1.3E-10) | −4.1E-02 (3.3E-54) | 4.4E-04 (1.0E-03) | −9.8E-02 (0.16) | 7.7E-03 (2.0E-02) | −1.7E-04 (0.37) |
| Pars triangularis | 0.36 (6.5E-10) | −3.8E-02 (3.6E-46) | −3.8E-05 (0.78) | −1.1E-01 (0.11) | 7.2E-03 (3.5E-02) | 2.9E-04 (0.13) |
| Pars orbitalis | 0.34 (3.9E-08) | −3.0E-02 (4.5E-27) | −6.3E-05 (0.67) | −3.2E-02 (0.67) | 6.3E-03 (0.098) | 4.5E-04 (2.6E-02) |
| Medial orbitofrontal | 0.49 (5.2E-14) | −2.5E-02 (1.6E-19) | 3.2E-04 (2.7E-02) | −4.0E-01 (1.2E-07) | −2.1E-03 (0.57) | 3.7E-04 (0.06) |
| Lateral orbitofrontal | 0.40 (3.1E-10) | −3.5E-02 (2.6E-40) | 1.0E-04 (0.46) | −3.4E-01 (2.3E-06) | 3.0E-03 (0.39) | 4.7E-04 (1.2E-02) |
| Precentral | 0.55 (9.6E-17) | −3.6E-02 (3.6E-43) | 9.3E-05 (0.48) | −9.9E-03 (0.89) | 4.9E-03 (0.14) | 8.7E-05 (0.64) |
| Paracentral | 0.61 (7.9E-18) | −2.9E-02 (1.5E-29) | 1.5E-04 (0.26) | 2.4E-01 (6.1E-04) | −3.8E-03 (0.26) | −8.4E-05 (0.65) |
| Postcentral | 0.64 (1.9E-24) | −3.6E-02 (1.1E-43) | 8.3E-05 (0.53) | 2.1E-01 (1.8E-03) | 4.4E-03 (0.18) | −8.4E-05 (0.64) |
| Superiorparietal | 0.42 (1.6E-10) | −3.6E-02 (1.2E-41) | 2.7E-04 (4.7E-02) | 2.5E-01 (4.1E-04) | 6.1E-03 (0.086) | −2.8E-04 (0.15) |
| Supramarginal | 0.46 (4.6E-12) | −4.5E-02 (2.9E-72) | 2.8E-04 (2.2E-02) | 2.1E-01 (1.2E-03) | 7.9E-03 (1.1E-02) | −9.2E-05 (0.59) |
| Inferior parietal | 0.37 (4.4E-10) | −4.6E-02 (2.6E-03) | 3.2E-04 (2.5E-03) | 2.0E-01 (8.6E-40) | 1.0E-02 (0.28) | −1.2E-04 (0.54) |
| Caudal anterior cingulate | 0.38 (3.3E-09) | −2.4E-02 (1.7E-16) | 4.8E-04 (1.5E-03) | 1.0E-01 (0.19) | 6.3E-03 (0.10) | 2.2E-04 (0.30) |
| Rostral anterior cingulate | 0.42 (1.8E-10) | −3.3E-02 (1.9E-35) | 6.0E-04 (1.2E-05) | −2.9E-01 (4.6E-05) | 1.7E-03 (0.63) | 4.0E-04 (3.3E-02) |
| Posterior cingulate | 0.44 (8.0E-12) | −3.8E-02 (5.8E-52) | 3.7E-04 (4.3E-03) | 1.6E-02 (0.80) | −1.2E-03 (0.71) | 2.7E-04 (0.12) |
| Isthmus cingulate | 0.63 (2.8E-23) | −4.0E-02 (5.5E-53) | 9.9E-05 (0.45) | 4.2E-02 (0.54) | 1.0E-02 (2.3E-03) | 1.5E-04 (0.40) |
| Superior temporal | 0.56 (2.0E-18) | −4.5E-02 (6.4E-77) | 1.8E-04 (0.13) | −4.6E-02 (0.46) | 8.9E-03 (3.3E-03) | −2.2E-04 (0.18) |
| Middle temporal | 0.41 (6.2E-11) | −4.2E-02 (3.0E-62) | 3.9E-04 (2.0E-03) | −0.12 (6.3E-02) | 7.7E-03 (1.6E-02) | 6.4E-05 (0.72) |
| Inferior temporal | 0.47 (3.5E-13) | −3.3E-02 (3.4E-34) | 4.6E-04 (9.4E-04) | −1.9E-02 (0.79) | 6.2E-03 (0.079) | 1.5E-04 (0.42) |
| Fusiform | 0.48 (2.5E-11) | −3.8E-02 (8.2E-49) | 2.3E-04 (0.076) | −7.0E-02 (0.31) | 4.2E-03 (0.21) | 9.8E-05 (0.59) |
| Parahippocampal | 0.47 (7.6E-11) | −1.9E-02 (3.8E-11) | 1.6E-04 (0.28) | −8.2E-02 (0.30) | −3.3E-03 (0.39) | −3.7E-05 (0.86) |
| Entorhinal | 0.35 (3.7E-08) | −1.5E-02 (1.3E-07) | −2.6E-04 (0.090) | −4.8E-01 (2.4E-09) | 4.4E-03 (0.25) | 7.1E-05 (0.74) |
| Precuneus | 0.55 (2.5E-17) | −4.3E-02 (3.7E-69) | 2.7E-04 (2.6E-02) | 7.2E-02 (0.25) | 4.2E-03 (0.18) | −2.8E-05 (0.87) |
| Cuneus | 0.43 (4.4E-10) | −4.3E-02 (3.3E-32) | 2.7E-04 (0.39) | 7.2E-02 (4.8E-04) | 4.2E-03 (0.30) | −2.8E-05 (0.44) |
| Lingual | 0.49 (3.2E-12) | −3.9E-02 (2.8E-50) | −9.9E-05 (0.46) | 8.9E-02 (0.19) | 6.6E-03 (4.9E-02) | −1.3E-06 (0.99) |
| Pericalcarine | 0.39 (2.8E-09) | −2.5E-02 (8.6E-19) | −1.4E-04 (0.33) | 3.9E-01 (3.4E-07) | 1.3E-03 (0.72) | −3.1E-04 (0.13) |
| Lateral occipital | 0.49 (4.3E-14) | −3.7E-02 (1.9E-43) | 3.8E-05 (0.78) | 1.7E-01 (1.5E-02) | 1.4E-02 (7.8E-05) | −1.7E-04 (0.37) |