Table V.
Statistics from region-based analysis of white matter FA in 819 subjects. Significant p-values are reported in scientific notation. A negative (positive) β for sex indicates the value of the phenotypic measure was generally smaller in females (males).
| White Matter Tract FA | h2 (p-value) | Age β (p-value) | Age2 β (p-value) | Sex β (p-value) | Age × Sex β (p-value) | Age2 × Sex β (p-value) |
|---|---|---|---|---|---|---|
| R S Longitudinal fasciculus | 0.61 (2.7E-13) | −2.9E-02 (9.6E-20) | 1.0E-05 (0.95) | −0.18 (3.0E-02) | −8.2E-03 (4.73E-02) | 2.7E-04 (0.28) |
| L S Longitudinal fasciculus | 0.59 (2.5E-14) | −2.6E-02 (8.9E-16) | 4.7E-05 (0.80) | −0.03 (0.71) | −1.0E-02 (1.27E-02) | 1.0E-04 (0.69) |
| Corpus callosum-genu | 0.62 (1.2E-14) | −4.1E-02 (6.5E-41) | −3.4E-05 (0.84) | −0.06 (0.41) | 6.9E-03 (0.07) | 7.7E-05 (0.74) |
| Corpus callosum-body | 0.48 (9.5E-12) | −3.7E-02 (1.7E-31) | −1.9E-04 (0.28) | 0.05 (0.54) | 4.9E-03 (0.23) | 6.2E-05 (0.80) |
| Corpus callosum-splenium | 0.62 (8.3E-15) | −3.3E-02 (1.5E-24) | −4.8E-05 (0.79) | −0.18 (2.6E-02) | −2.3E-05 (1.00) | 3.6E-04 (0.15) |
| R Cingulate-Hippocampus | 0.40 (2.1E-06) | −7.9E-03 (2.7E-02) | 4.1E-04 (0.05) | −0.34(2.5E-04) | −5.9E-03 (0.22) | −1.9E-04 (0.51) |
| L Cingulate-Hippocampus | 0.31 (8.0E-05) | −3.8E-03 (0.29) | 3.4E-04 (0.12) | −0.42 (8.3E-06) | −4.8E-03 (0.32) | −2.9E-05 (0.92) |
| R Cingulate | 0.47 (2.8E-09) | −2.8E-02 (2.5E-17) | −4.9E-04 (9.9E-03) | −0.33 (9.2E-05) | −2.2E-03 (0.60) | 4.3E-04 (0.09) |
| L Cingulate | 0.46 (1.1E-08) | −3.0E-02 (4.6E-21) | −3.6E-04 (0.06) | −0.34 (2.8E-05) | −1.7E-03 (0.68) | 3.6E-04 (0.15) |
| R P limb of IC | 0.42 (4.5E-08) | −2.1E-02 (6.3E-10) | 2.2E-04 (0.27) | −0.02 (0.80) | −8.7E-03 (0.05) | 7.0E-05 (0.80) |
| L P limb of IC | 0.44 (4.2E-09) | −1.9E-02 (3.4E-08) | 2.8E-04 (0.17) | 0.02 (0.83) | −7.2E-03 (0.12) | −3.7E-06 (0.99) |
| R A limb of IC | 0.49 (2.3E-10) | −2.6E-02 (8.6E-15) | 1.8E-04 (0.35) | −0.15 (0.08) | −6.4E-03 (0.14) | 6.3E-05 (0.81) |
| L A Iimb of IC | 0.47 (6.3E-10) | −2.4E-02 (9.8E-13) | 2.7E-05 (0.89) | −0.24 (5.8E-03) | −5.2E-03 (0.24) | 1.5E-04 (0.58) |
| R Retrolenticular IC | 0.34 (1.1E-05) | −2.0E-02 (2.3E-09) | 4.0E-04 (4.6E-02) | −0.32 (2.4E-04) | −8.1E-03 (0.07) | 1.9E-04 (0.47) |
| L Retrolenticular IC | 0.30 (6.1E-05) | −2.1E-02 (2.2E-09) | 4.5E-04 (2.6E-02) | −0.16 (0.07) | −9.9E-03 (2.81E-02) | 1.1E-04 (0.70) |
| R External capsule | 0.54 (5.0E-11) | −3.4E-02 (7.2E-27) | 4.6E-05 (0.80) | −0.14 (0.08) | −4.0E-03 (0.33) | 1.0E-04 (0.68) |
| L External capsule | 0.49 (4.8E-10) | −3.3E-02 (5.5E-24) | −1.5E-05 (0.94) | −0.08 (0.34) | −3.2E-03 (0.45) | −8.3E-05 (0.74) |
| R P Thalamic radiations | 0.42 (1.2E-08) | −4.0E-02 (4.3E-35) | −1.7E-04 (0.34) | −0.07 (0.39) | 3.7E-03 (0.36) | 4.1E-04 (0.09) |
| L P Thalamic radiations | 0.46 (4.2E-11) | −3.3E-02 (4.7E-25) | −9.1E-05 (0.62) | 0.07 (0.41) | 3.7E-04 (0.93) | 2.6E-04 (0.30) |
| R S Corona radiata | 0.52 (6.9E-11) | −3.3E-02 (1.6E-24) | 8.7E-05 (0.63) | 0.19 (1.8E-02) | −2.6E-03 (0.53) | −9.4E-05 (0.70) |
| L S Corona radiata | 0.52 (2.7E-12) | −3.1E-02 (6.1E-23) | 5.6E-05 (0.76) | 0.19 (1.9E-02) | −5.1E-03 (0.21) | −1.1E-04 (0.67) |
| R A Corona radiata | 0.55 (2.2E-12) | −4.0E-02 (1.9E-37) | 2.7E-04 (0.13) | −0.03 (0.74) | 5.3E-03 (0.18) | 2.3E-06 (0.99) |
| L A Corona radiata | 0.50 (3.7E-11) | −3.8E-02 (8.4E-34) | −2.4E-05 (0.89) | −0.07 (0.38) | 1.0E-05 (1.00) | 1.4E-04 (0.55) |
| R P Corona radiata | 0.51 (4.2E-12) | −3.2E-02 (4.6E-23) | −1.4E-04 (0.47) | −0.02 (0.79) | 1.1E-03 (0.79) | 9.9E-05 (0.70) |
| L P Corona radiata | 0.42 (1.7E-09) | −3.3E-02 (2.4E-23) | −1.6E-04 (0.41) | 0.08 (0.31) | 3.9E-03 (0.36) | −2.4E-05 (0.93) |
| Mean FA | 0.55 (1.1E-12) | −3.8E-02 (7.8E-34) | −7.4E-05 (0.67) | −0.15 (0.05) | −8.7E-04 (0.82) | 1.9E-04 (0.43) |
FA = fractional anisotropy, R = right, L = left, S = superior, P = posterior, A = anterior, IC = internal capsule