Table 1.

Animal, hemodynamic, and morphological - mechanical data for common carotid arteries for seven different groups: control data pooled from Acta2^+/+ and Fbn1^mgR/+ mice compared with data from fibrillin-1 deficient (Fbn1^mgR/mgR), fibulin-5 null (Fbln5^−/−), angiotensin-II infused ApoE null (Ang-II ApoE^−/−), smooth muscle α-actin null (Acta2^−/−), dystrophin deficient (mdx), and sarcoglycan-δ null (Sgcd^−/−).

	Control	Fbn1 mgR/mgR	Fbln5 −/−	Ang-II ApoE −/−	Acta2 −/−	mdx	Sgcd −/−
n	16	6	5	8	7	5	6
Age (weeks)	9.0 ± 0.4	8.0 ± 0.2	21.2 ± 0.6	12.2 ± 0.1	10.6 ± 0.5	10.0 ± 0.9	10.0 ± 0.8
Body Mass (g)	22.9 ± 0.9	20.1 ± 2.3	33.6 ± 2.2	29.1 ± 1.4	26.3 ± 0.8	29.1 ± 0.5	26.7 ± 0.4
Blood Pressure (mmHg)
Systolic	116 ± 2a,c	131 ± 6b	152 ± 2e	157 ± 7d	82 ± 2a	80 ± 2f	88 ± 1f
Mean	-	107 ± 6b	122 ± 1e	133 ± 2d	-	-	-
Adjusted Systolic†	116	131	152	159	81	106	116
Unloaded Dimensions
Outer Diameter (μm)	394 ± 8	399 ± 6	429 ± 8	429 ± 7*	442 ± 5*	434 ± 7*	419 ± 11
Wall Thickness (μm)	94 ± 4	94 ± 5	70 ± 4*	109 ± 5	78 ± 3	63 ± 2*	62 ± 2*
In-vitro Axial Length (mm)	4.66 ± 0.21	4.14 ± 0.43	5.48 ± 0.35	4.46 ± 0.28	4.30 ± 0.21	4.86 ± 0.26	4.71 ± 0.30
Systolic Dimensions
Outer Diameter (μm)	647 ± 9	656 ± 16	579 ± 9*	680 ± 15	647 ± 7	618 ± 17	619 ± 14
Wall Thickness (μm)	26 ± 1	28 ± 1	33 ± 2*	34 ± 2*	28 ± 1	22 ± 1	20 ± 1*
In-vivo Axial Stretch	1.72 ± 0.02	1.61 ± 0.03	1.40 ± 0.02*	1.60 ± 0.05*	1.63 ± 0.03	1.77 ± 0.02	1.80 ± 0.01
Systolic Cauchy Stresses (kPa)
Circumferential	177.3 ± 5.1	186.8 ± 5.6	160.5 ± 13.7	195.7 ± 11.1	113.9 ± 4.6*	182.8 ± 11.1	219.4 ± 5.7*
Axial	199.7 ± 7.4	164.7 ± 6.3	189.1 ± 23.3	216.6 ± 10.3	182.8 ± 9.3	221.5 ± 10.8	265.4 ± 6.8*
Systolic Stiffness
Circumferential (MPa)	1.46 ± 0.10	1.79 ± 0.11	1.94 ± 0.27	1.86 ± 0.13	0.91 ± 0.11*	1.54 ± 0.13	1.97 ± 0.14
Axial (MPa)	3.03 ± 0.26	2.45 ± 0.29	5.33 ± 0.64*	3.41 ± 0.15	1.62 ± 0.08*	2.52 ± 0.23	2.94 ± 0.19
Pulse Wave Velocity (m/s)	7.74 ± 0.29	8.88 ± 0.31	10.65 ± 0.42*	9.71 ± 0.17*	6.30 ± 0.29*	7.48 ± 0.28	8.07 ± 0.30
Systolic Stored Energy (kPa)	50.4 ± 2.3	36.3 ± 1.5*	26.6 ± 3.6*	48.8 ± 3.5	47.7 ± 3.1	54.4 ± 4.5	63.1 ± 0.9*

Blood pressures (systolic, and mean when available) were compiled from reports in the literature [^a measured by tail-cuff ^{45; b} measured by indwelling catheter^{37; c} measured by tail-cuff ^{24; d} measured by tail-cuff ^{3; e} measured by indwelling catheter^{54; f} measured by left-ventricular catheter under isoflurane anesthesia⁴⁷], but also adjusted to a common central arterial value in the conscious mouse (cf. Appendix) to enable more consistent comparisons of model-specific properties. Actual mechanical data for the Fbn1^mgR/mgR mice were taken from Ferruzzi et al.¹⁴, those for Ang II ApoE^−/− mice from Bersi et al.², and those for the mdx and Sgcd^−/− mice from Dye et al.¹⁰; these data are collected together here for the first time, however, and re-analyzed consistently for purposes of direct comparison. The other mechanical data are new and from the authors’ laboratory. All data are presented as mean ± standard error of the mean. A superscript * denotes a significant difference relative to control based on an ANOVA, with a post-hoc Bonferroni correction, with p < 0.05 considered significant. Finally, albeit not shown, systolic pressures and in vivo axial stretches for the four aortic banding groups were: 120 mmHg and stretch of 1.70 for 0 day, 149 mmHg and 1.46 for 7–10 days, 154 mmHg and 1.37 for 10–14 days, and 125 mmHg and 1.27 for 35–56 days post-banding, respectively, with other information tabulated in Eberth et al.^12,13.