TABLE 2.
mRNA expression in mean RQ ± SEM in the brain from pups exposed to alcohol (8 litters) and saline (7 litters)
| Enzyme | Alcohol (n = 8) | Control (n = 7) | P value |
|---|---|---|---|
| DUOX1 | 1.14 ± 0.13 | 1.12 ± 0.11 | .89 |
| DUOX2 | 1.61 ± 0.28a | 0.84 ± 0.09 | .03 |
| NOX1 | 0.95 ± 0.95 | 0.72 ± 0.72 | .23 |
| NOX2 | 1.46 ± 0.20 | 1.08 ± 0.06 | .11 |
| NOX3 | 1.48 ± 0.25 | 1.07 ± 0.07 | .15 |
| NOX4 | 1.66 ± 0.15 | 1.28 ± 0.25 | .21 |
| NOXA1 | 1.75 ± 0.27a | 1.09 ± 0.06 | .04 |
| NOXO1 | 1.59 ± 0.10a | 1.28 ± 0.05 | .02 |
| RAC1 | 1.10 ± 0.12 | 1.17 ± 0.11 | .66 |
| p22phox | 1.76 ± 0.22 | 1.82 ± 0.15 | .82 |
| p67phox | 1.55 ± 0.20 | 1.38 ± 0.09 | .51 |
RQ, relative quantity.
a
Denotes statistically significant differences (P < .05) between the groups.
Hill. NADPH oxidase and fetal alcohol syndrome. Am J Obstet Gynecol 2014.