Skip to main content
. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: J Immunol. 2014 Apr 9;192(10):4571–4580. doi: 10.4049/jimmunol.1400007

FIGURE 5.

FIGURE 5

Distinct TCR Vβ5.1 CDR3β sequences in tethi and tetlo CD4+ T cells. (A) Density plots of HLA-DP2-mimotope-2/Be tetramer and TCR Vβ5.1 staining of CD4+ T cells from BAL-derived T cell lines of CBD patients 1435 and 1056 are shown. The tethi and tetlo Vβ5.1+ CD4+ T cell subsets are enclosed in solid and dashed circles, respectively. The percentage of the various staining subsets is also shown. Deduced Vβ5.1 CDR3 amino acid sequences in the tethi and tetlo CD4+ T cell populations of CBD patients 1435 (B) and 1056 (C) are shown. Variation between the tethi and tetlo T cell populations lies in the amino acids comprising the first position of the NDβN region. The number of identical sequences (defined at the nucleotide level) is shown over the total number of sequences analyzed. Bolded amino acids denote those that are encoded by all non-template nucleotides or a combination of non-template and germline encoded nucleotides.